Sanford Health and the University of South Dakota collaborated to develop more effective drug-coated balloons to treat peripheral artery disease. The two devices, which can more precisely deliver drugs to specific arteries, are based on intellectual property jointly created by Sanford’s Patrick Kelly, M.D., and USD’s Gopinath Mani, Ph.D.
Drug-coated balloons deliver drugs to arteries to repair damaged walls and prevent future narrowing. Traditional balloons release drugs in a burst. This requires more balloons and releases medicine to areas that don’t need it.
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Time-release drug-coated balloons
The methods Mani and Kelly designed use a special coating to time the release of medicine. This prevents release of the drug while tracking to the target site and allows for treatment in multiple areas.
Kelly is a board-certified and fellowship-trained vascular and general surgeon. Also a clinical research scientist with Sanford Research, he holds dozens of patents and patent applications for medical devices and has run several clinical trials.
Mani is an assistant professor in USD’s biomedical engineering program. He has published more than 25 peer-reviewed research articles and currently has four patents pending on next-generation cardiovascular medical devices.
“This time-released method of delivering drugs via balloons is economical and may reduce the amount of unneeded chemo therapeutic agent that enters the body,” said Kelly. “If this technology works the way we think it will, we may also be able to use fewer of these costly balloons.”
Two methods discovered
One of the methods developed by Kelly and Mani uses dextran sulfate polymer to control the release of medicine and is outlined in a recent paper published in the Journal of Biomedical Materials Research Part B: Applied Biomaterials. The other method uses a polyethylene oxide coating on the balloon. Its success was demonstrated in another paper that appeared in Acta Biomaterialia.
“Our technology uses novel polymeric biomaterials to tailor the drug release in such a way that the drug will be delivered only at the treatment site without any drug loss in the blood stream. We are very excited that this technology provides the right platform to develop next generation drug-coated balloons. These balloons are expected to provide an effective treatment and improve the quality of life of patients,” said Mani.
While stents treat artery blockage, they are limited in certain areas of the body, like the legs.
This article was originally published in 2015.